GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs13256369 | 1 | rs9329165 | chr8:8576642 | CLDN23 | chr8:8559666-8561616:+ | 0.22 | 3.88 | 0.000124 | Obesity-related traits |
| BLCA | cis | rs10935120 | 1 | rs934093 | chr3:134195885 | ANAPC13 | chr3:134196547-134204865:- | 0.51 | 8.15 | 5.16E-15 | Height |
| BLCA | cis | rs10935120 | 1 | rs934093 | chr3:134195885 | CEP63 | chr3:134204575-134293852:+ | 0.25 | 4.41 | 1.33E-5 | Height |
| BLCA | cis | rs1474698 | 1 | rs9349804 | chr6:56098876 | COL21A1 | chr6:55921389-56258892:- | 0.36 | 6.56 | 1.79E-10 | Pulse pressure |
| BLCA | cis | rs7246967 | 1 | rs936525 | chr19:23056189 | ZNF492 | chr19:22817126-22850472:+ | -0.3 | -4.2 | 3.34E-5 | Bronchopulmonary dysplasia |
| BLCA | cis | rs7246967 | 1 | rs936526 | chr19:23055987 | ZNF492 | chr19:22817126-22850472:+ | -0.3 | -4.03 | 6.82E-5 | Bronchopulmonary dysplasia |
| BLCA | cis | rs9369898 | 1 | rs9369898 | chr6:49382193 | CENPQ | chr6:49431096-49460820:+ | -0.4 | -8.67 | 1.24E-16 | Homocysteine levels |
| BLCA | cis | rs2243480 | 1 | rs937108 | chr7:65428452 | CCT6P1 | chr7:65216092-65228661:+ | 0.33 | 4.53 | 7.78E-6 | Diabetic kidney disease |
| BLCA | cis | rs9371538 | 1 | rs9371221 | chr6:151885986 | C6orf97 | chr6:151815175-151942327:+ | 0.28 | 4.21 | 3.14E-5 | Bone mineral density (spine) |
| BLCA | cis | rs9322193 | 1 | rs9377229 | chr6:149928791 | NUP43 | chr6:150045453-150067688:- | -0.29 | -4.65 | 4.67E-6 | Lung cancer |
| BLCA | cis | rs9381040 | 1 | rs9381040 | chr6:41154650 | LOC221442 | chr6:41068773-41108567:+ | 0.24 | 4.27 | 2.47E-5 | Alzheimer's disease (late onset) |
| BLCA | cis | rs9296504 | 1 | rs9381469 | chr6:46630068 | SLC25A27 | chr6:46620679-46645925:+ | -0.24 | -4.83 | 1.94E-6 | QRS complex (Sokolow-Lyon) |
| BLCA | cis | rs9369898 | 1 | rs9381784 | chr6:49398115 | CENPQ | chr6:49431096-49460820:+ | 0.38 | 8.03 | 1.23E-14 | Homocysteine levels |
| BLCA | cis | rs1401999 | 1 | rs939337 | chr3:183701147 | ABCC5 | chr3:183637726-183735727:- | -0.21 | -4.1 | 4.97E-5 | Anterior chamber depth |
| BLCA | cis | rs1401999 | 1 | rs939338 | chr3:183704068 | VWA5B2 | chr3:183948317-183960116:+ | 0.23 | 3.86 | 0.000131 | Anterior chamber depth |